Analysis of Three Epoetin Alpha Products by LC and LC-MS Indicates Differences in Glycosylation Critical Quality Attributes, Including Sialic Acid Content
نویسندگان
چکیده
منابع مشابه
[Determination of pindone in agricultural products by LC-MS/MS].
A sensitive and selective analytical method for the determination of pindone in agricultural products by LC-MS/MS was developed. Pindone was extracted with acetone, and an aliquot of the crude extract was re-extracted with hexane. For lipid-rich samples, the crude extract was further cleaned up by acetonitrile-hexane partitioning. The extract was cleaned up on a tandem graphitized carbon-silica...
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A method using liquid chromatography with tandem mass spectrometry has been developed for the determination of clomeprop and its metabolite clomeprop acid in livestock and seafood products. Clomeprop and clomeprop acid were extracted with acetone-n-hexane mixture under acidic conditions, and were defatted by liquid-liquid separation using acetonitrile and n-hexane, followed cleanup with SAX and...
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In the present study, comprehensive stress testing of amlodipine (AM) was carried out according to International Conference on Harmonization (ICH) Q1A(R2) guideline. AM was subjected to acidic, neutral and alkaline hydrolysis, oxidation, photolysis and thermal stress conditions. The drug showed instability in acidic and alkaline conditions, while it remained stable to neutral, oxidative, light ...
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Degradation products of itopride formed under different forced conditions have been identified using LC-PDA and LC-MS techniques. Itopride was subjected to forced degradation under the conditions of hydrolysis, photolysis, oxidation, dry and wet heat, in accordance with the International Conference on Harmonization. The stress solutions were chromatographed on reversed phase C18 (250×4.6 mm, 5 ...
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Liquid chromatography/mass spectrometry (LC/MS), combining good separation characteristics with highly specific and sensitive detection, is the method of choice for forensic trace analysis of explosives. Principles of operation and instrumentation of several LC/MS interface/ionization modes are described. Among the various LC/MS interfaces and ionization modes, electrospray ionization (ESI)-LC/...
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ژورنال
عنوان ژورنال: Analytical Chemistry
سال: 2017
ISSN: 0003-2700,1520-6882
DOI: 10.1021/acs.analchem.7b00353